New chemically induced skin tumour susceptibility loci identified in a mouse backcross between FVB and dominant resistant PWK

DOI PDF PubMed 被引用文献6件 オープンアクセス

書誌事項

公開日
2007-06-28
DOI
  • 10.1186/1471-2156-8-39
公開者
Springer Science and Business Media LLC

説明

<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>A variety of skin cancer susceptibility among mouse strains has allowed identification of genes responsible for skin cancer development. Fifteen<jats:italic>Skts</jats:italic>loci for skin tumour susceptibility have been mapped so far by using the two-stage skin carcinogenesis model [induced by 7.12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)]. A few responsible genes have been identified using wild-derived dominant resistant<jats:italic>Mus spretus</jats:italic>mice, and one has been confirmed as a low penetrance cancer susceptibility gene in a variety of human cancers.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>In the present study, we found that wild-derived PWK mice developed no tumour by treatment with the two-stage skin carcinogenesis protocol. This phenotype is dominant resistant when crossed with the highly susceptible strain FVB. By analyzing the F1 backcross generation between PWK and FVB, we found empirical evidence of significant linkage at the new loci<jats:italic>Skts-fp1</jats:italic>on chromosome 4 and suggestive linkage on chromosomes 1, 3, 11, 12 and 14 for skin tumour susceptibility.<jats:italic>Skts-fp1</jats:italic>includes the<jats:italic>Skts7</jats:italic>interval, which was previously mapped by a<jats:italic>Mus spretus</jats:italic>and NIH backcross. We also observed suggestive linkage on chromosomes 1 and 2 in the female population only, while suggestive linkage on chromosomes 14 and 15 only was observed in the male population. A significant genetic interaction was seen between markers of<jats:italic>D11Mit339</jats:italic>and<jats:italic>D16Mit14</jats:italic>.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Analysis of this new cross may facilitate the identification of genes responsible for mouse skin cancer susceptibility and may reveal their biological interactions.</jats:p></jats:sec>

収録刊行物

  • BMC Genetics

    BMC Genetics 8 (1), 39-, 2007-06-28

    Springer Science and Business Media LLC

被引用文献 (6)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ