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- Debajit K. Biswas
- Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Surgery, Brigham and Women’s Hospital, Boston, MA 02115, USA.
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- Sindhu Singh
- Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Surgery, Brigham and Women’s Hospital, Boston, MA 02115, USA.
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- Qian Shi
- Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Surgery, Brigham and Women’s Hospital, Boston, MA 02115, USA.
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- Arthur B. Pardee
- Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Surgery, Brigham and Women’s Hospital, Boston, MA 02115, USA.
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- J. Dirk Iglehart
- Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Surgery, Brigham and Women’s Hospital, Boston, MA 02115, USA.
書誌事項
- 公開日
- 2005-06-14
- DOI
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- 10.1126/stke.2882005pe27
- 公開者
- American Association for the Advancement of Science (AAAS)
説明
<jats:p>Cellular homeostasis in higher organisms is maintained by balancing cell growth, differentiation, and death. Two important systems that transmit extracellular signals into the machinery of the cell nucleus are the signaling pathways that activate nuclear factor κB (NF-κΒ) and estrogen receptor (ER). These two transcription factors induce expression of genes that control cell fates, including proliferation and cell death (apoptosis). However, ER has anti-inflammatory effects, whereas activated NF-κB initiates and maintains cellular inflammatory responses. Recent investigations elucidated a nonclassical and nongenomic effect of ER: inhibition of NF-κB activation and the inflammatory response. In breast cancer, antiestrogen therapy might cause reactivation of NF-κB, potentially rerouting a proliferative signal to breast cancer cells and contributing to hormone resistance. Thus, ER ligands that selectively block NF-κB activation could provide specific potential therapy for hormone-resistant ER-positive breast cancers.</jats:p>
収録刊行物
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- Science's STKE
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Science's STKE 2005 (288), pe27-, 2005-06-14
American Association for the Advancement of Science (AAAS)
