Ablation of Insulin-Producing Neurons in Flies: Growth and Diabetic Phenotypes
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- Eric J. Rulifson
- Department of Developmental Biology,
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- Seung K. Kim
- Department of Developmental Biology,
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- Roel Nusse
- Department of Developmental Biology,
書誌事項
- 公開日
- 2002-05-10
- DOI
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- 10.1126/science.1070058
- 公開者
- American Association for the Advancement of Science (AAAS)
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説明
<jats:p> In the fruit fly <jats:italic>Drosophila</jats:italic> , four insulin genes are coexpressed in small clusters of cells [insulin-producing cells (IPCs)] in the brain. Here, we show that ablation of these IPCs causes developmental delay, growth retardation, and elevated carbohydrate levels in larval hemolymph. All of the defects were reversed by ectopic expression of a <jats:italic>Drosophila</jats:italic> insulin transgene. On the basis of these functional data and the observation that IPCs release insulin into the circulatory system, we conclude that brain IPCs are the main systemic supply of insulin during larval growth. We propose that IPCs and pancreatic islet β cells are functionally analogous and may have evolved from a common ancestral insulin-producing neuron. Interestingly, the phenotype of flies lacking IPCs includes certain features of diabetes mellitus. </jats:p>
収録刊行物
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- Science
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Science 296 (5570), 1118-1120, 2002-05-10
American Association for the Advancement of Science (AAAS)
