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- Subhash Padhye
- Department of Pathology Barbara Ann Karmanos Cancer Institute Wayne State University School of Medicine Hudson Webber Cancer Research Center Detroit Michigan
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- Prasad Dandawate
- Department of Chemistry MCE Society's Abeda Inamdar Senior College of Arts Science and Commerce Pune India
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- Mujahid Yusufi
- Department of Chemistry MCE Society's Abeda Inamdar Senior College of Arts Science and Commerce Pune India
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- Aamir Ahmad
- Department of Pathology Barbara Ann Karmanos Cancer Institute Wayne State University School of Medicine Hudson Webber Cancer Research Center Detroit Michigan
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- Fazlul H. Sarkar
- Department of Pathology Barbara Ann Karmanos Cancer Institute Wayne State University School of Medicine Hudson Webber Cancer Research Center Detroit Michigan
書誌事項
- 公開日
- 2010-11-09
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/med.20235
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>Plumbagin is one of the simplest plant secondary metabolite of three major phylogenic families viz. <jats:italic>Plumbaginaceae</jats:italic>, <jats:italic>Droseraceae</jats:italic>, <jats:italic>and Ebenceae</jats:italic>, and exhibits highly potent biological activities, including antioxidant, antiinflammatory, anticancer, antibacterial, and antifungal activities. Recent investigations indicate that these activities arise mainly out of its ability to undergo redox cycling, generating reactive oxygen species and chelating trace metals in biological system. The compound is endowed with a property to inhibit the drug efflux mechanism in drug‐resistant bacteria, thereby allowing intracellular accumulation of the potent drug molecules. An interesting bioactivity exhibited by this compound is the elimination of stringent, conjugative, multidrug‐resistant plasmids from several bacterial strains including opportunistic bacteria, such as <jats:italic>Acinetobacter baumannii</jats:italic>. Moreover, plumbagin effectively induces apoptosis and causes cell cycle arrest, which is, in part, due to the inactivation of NF‐κB in cancer cells. Therefore, it has been suggested that designing “hybrid drug molecules” of plumbagin by combining it with other appropriate anticancer agents may lead to the generation of novel and potent anticancer drugs with pleiotropic action against human cancers. This comprehensive review is an attempt to understand the chemistry of plumbagin and catalog its biological activities reported to date.</jats:p>
収録刊行物
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- Medicinal Research Reviews
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Medicinal Research Reviews 32 (6), 1131-1158, 2010-11-09
Wiley
