Silica‐associated lung disease: An old‐world exposure in modern industries
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- Hayley Barnes
- Department of Respiratory Medicine Alfred Hospital Melbourne VIC Australia
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- Nicole S.L. Goh
- Department of Respiratory Medicine Alfred Hospital Melbourne VIC Australia
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- Tracy L. Leong
- Department of Respiratory Medicine Austin Hospital Melbourne VIC Australia
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- Ryan Hoy
- Department of Medicine University of Melbourne Melbourne VIC Australia
書誌事項
- 公開日
- 2019-09-13
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/resp.13695
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>ABSTRACT</jats:title><jats:p>Despite silica dust exposure being one of the earliest recognized causes of lung disease, Australia, USA, Israel, Turkey and other countries around the world have recently experienced significant outbreaks of silicosis. These outbreaks have occurred in modern industries such as denim jean production, domestic benchtop fabrication and jewellery polishing, where silica has been introduced without recognition and control of the hazard. Much of our understanding of silica‐related lung disease is derived from traditional occupations such as mining, whereby workers may develop slowly progressive chronic silicosis. However, workers in modern industries are developing acute and accelerated silicosis over a short period of time, due to high‐intensity silica concentrations, oxidative stress from freshly fractured silica and a rapid pro‐inflammatory and pro‐fibrotic response. Appropriate methods of screening and diagnosis remain unclear in these workers, and a significant proportion may go on to develop respiratory failure and death. There are no current effective treatments for silicosis. For those with near fatal respiratory failure, lung transplantation remains the only option. Strategies to reduce high‐intensity silica dust exposure, enforced screening programmes and the identification of new treatments are urgently required.</jats:p>
収録刊行物
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- Respirology
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Respirology 24 (12), 1165-1175, 2019-09-13
Wiley
