Pd‐Catalyzed Regioselective Activation of <i>gem</i>‐Difluorinated Cyclopropanes: A Highly Efficient Approach to 2‐Fluorinated Allylic Scaffolds

Jun Xu, Ebrahim‐Alkhalil Ahmed, Bin Xiao, Qian‐Qian Lu, Yun‐Long Wang, Chu‐Guo Yu, Yao Fu

doi:10.1002/anie.201502308

Pd‐Catalyzed Regioselective Activation of <i>gem</i>‐Difluorinated Cyclopropanes: A Highly Efficient Approach to 2‐Fluorinated Allylic Scaffolds

DOI Web Site Web Site 被引用文献3件

書誌事項

公開日: 2015-06

権利情報

http://onlinelibrary.wiley.com/termsAndConditions#vor

DOI

10.1002/anie.201502308

公開者: Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>An unprecedented Pd‐catalyzed regioselective activation of gem‐difluorinated cyclopropanes induced by CC bond cleavage is reported. It provides a general and efficient access to a variety of 2‐fluoroallylic amines, ethers, esters, and alkylation products in high Z‐selectivity, which are important skeletons in many biologically active molecules. In addition, the transformation represents the first general application of gem‐difluorinated cyclopropanes as reaction partners in transition‐metal‐catalyzed cross‐coupling reaction.</jats:p>