Evaluation of Traditional Chinese Medicinal Plants for Anti-MRSA Activity with Reference to the Treatment Record of Infectious Diseases

DOI Web Site 1 Citations
  • Guo-Ying Zuo
    Research Center for Natural Medicines, Kunming General Hospital, PLA, Kunming 650032, China
  • Xin-Juan Zhang
    Research Center for Natural Medicines, Kunming General Hospital, PLA, Kunming 650032, China
  • Cui-Xian Yang
    Research Center for Natural Medicines, Kunming General Hospital, PLA, Kunming 650032, China
  • Jun Han
    Yunnan Traditional Chinese Medical College, Kunming 650500, China
  • Gen-Chun Wang
    Research Center for Natural Medicines, Kunming General Hospital, PLA, Kunming 650032, China
  • Zhong-Qi Bian
    Center for Infectious Diseases, Kunming General Hospital, PLA, Kunming 650032, China

Description

<jats:p>The in vitro antimicrobial activities of 30 Chinese medicinal plants were evaluated with reference to the treatment record of infectious diseases in the Traditional Chinese Medicine (TCM) literature. The plant materials were extracted with 80% ethanol and the extracts were primarily screened against conventional clinical pathogens like Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans by the agar diffusion method. Their inhibition zone diameters (IZDs, mm, 50 mg/mL) ranged from 2,048 by the standard broth microdilution method. The seven extracts from M. yunnanensis, S. sinensis, G. morella, E. daneillii, M. squamulata, S. arborescens and B. hancei were determined as the most active extracts, with MICs of 8–64 μg/mL. The results were in good agreement with their traditional applications in skin and other infections.</jats:p>

Journal

  • Molecules

    Molecules 17 (3), 2955-2967, 2012-03-09

    MDPI AG

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