BI-DIRECTIONAL PROTEIN TRANSPORT BETWEEN THE ER AND GOLGI

DOI Web Site 21 Citations
  • Marcus C.S. Lee
    Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, California;
  • Elizabeth A. Miller
    Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, California;
  • Jonathan Goldberg
    Howard Hughes Medical Institute and Memorial Sloan-Kettering Cancer Center, New York;
  • Lelio Orci
    Department of Morphology, University of Geneva Medical School, Switzerland;
  • Randy Schekman
    Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, California;

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<jats:p> ▪ Abstract  The endoplasmic reticulum (ER) and the Golgi comprise the first two steps in protein secretion. Vesicular carriers mediate a continuous flux of proteins and lipids between these compartments, reflecting the transport of newly synthesized proteins out of the ER and the retrieval of escaped ER residents and vesicle machinery. Anterograde and retrograde transport is mediated by distinct sets of cytosolic coat proteins, the COPII and COPI coats, respectively, which act on the membrane to capture cargo proteins into nascent vesicles. We review the mechanisms that govern coat recruitment to the membrane, cargo capture into a transport vesicle, and accurate delivery to the target organelle. </jats:p>

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