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- Marcus C.S. Lee
- Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, California;
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- Elizabeth A. Miller
- Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, California;
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- Jonathan Goldberg
- Howard Hughes Medical Institute and Memorial Sloan-Kettering Cancer Center, New York;
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- Lelio Orci
- Department of Morphology, University of Geneva Medical School, Switzerland;
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- Randy Schekman
- Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, California;
説明
<jats:p> ▪ Abstract The endoplasmic reticulum (ER) and the Golgi comprise the first two steps in protein secretion. Vesicular carriers mediate a continuous flux of proteins and lipids between these compartments, reflecting the transport of newly synthesized proteins out of the ER and the retrieval of escaped ER residents and vesicle machinery. Anterograde and retrograde transport is mediated by distinct sets of cytosolic coat proteins, the COPII and COPI coats, respectively, which act on the membrane to capture cargo proteins into nascent vesicles. We review the mechanisms that govern coat recruitment to the membrane, cargo capture into a transport vesicle, and accurate delivery to the target organelle. </jats:p>
収録刊行物
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- Annual Review of Cell and Developmental Biology
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Annual Review of Cell and Developmental Biology 20 (1), 87-123, 2004-11-01
Annual Reviews
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詳細情報 詳細情報について
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- CRID
- 1363951793989797120
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- ISSN
- 15308995
- 10810706
- http://id.crossref.org/issn/10810706
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- データソース種別
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- Crossref