MAP kinase binds to the NH<sub>2</sub>‐terminal activation domain of c‐Myc

Shashi Gupta, Roger J. Davis

doi:10.1016/0014-5793(94)01052-8

MAP kinase binds to the NH<sub>2</sub>‐terminal activation domain of c‐Myc

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書誌事項

公開日: 1994-10-24

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http://onlinelibrary.wiley.com/termsAndConditions#vor

DOI

10.1016/0014-5793(94)01052-8

公開者: Wiley

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説明

<jats:p>The transcription factor c‐Myc is a substrate for phosphorylation by MAP kinases. Here we demonstrate that MAP kinase binds to c‐Myc. The NH<jats:sub>2</jats:sub>‐terminal region (residues 1–100) is necessary and sufficient for this interaction. Binding to c‐Myc is not dependent on the state of MAP kinase activation. However, the c‐Myc/MAP kinase complex is disrupted by ATP. Together, these observations indicate that substrate binding interactions contribute to the specificity of phosphorylation by MAP kinases.</jats:p>