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- Toshihiro Houdai
- Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Toyonaka, Osaka 560- 0043, Japan
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- Nobuaki Matsumori
- Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Toyonaka, Osaka 560- 0043, Japan
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- Michio Murata
- Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Toyonaka, Osaka 560- 0043, Japan
書誌事項
- 公開日
- 2008-09-04
- DOI
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- 10.1021/ol8016337
- 公開者
- American Chemical Society (ACS)
この論文をさがす
説明
Amphidinol 3 (AM3) exhibits a potent membrane permeabilizing activity by forming pores in biological membranes. We examined the conformation and location of AM3 using isotropic bicelles, a more natural membrane model than micelles. The results show that AM3 takes turn structures at the two tetrahydropyran rings. Most of the hydrophilic region of the molecule is predominantly present in the surface, while the hydrophobic polyolefin penetrates in the bicelle interior.
収録刊行物
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- Organic Letters
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Organic Letters 10 (19), 4191-4194, 2008-09-04
American Chemical Society (ACS)
