-
- Volker Ott
- Department of Neuroendocrinology, University of Lübeck, Lübeck, Germany
-
- Graham Finlayson
- Institute of Psychological Sciences, University of Leeds, Leeds, U.K.
-
- Hendrik Lehnert
- Department of Internal Medicine I, University of Lübeck, Lübeck, Germany
-
- Birte Heitmann
- Department of Neuroendocrinology, University of Lübeck, Lübeck, Germany
-
- Markus Heinrichs
- Laboratory for Biological and Personality Psychology, Department of Psychology, University of Freiburg, Freiburg, Germany
-
- Jan Born
- Department of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany
-
- Manfred Hallschmid
- Department of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany
書誌事項
- 公開日
- 2013-09-17
- 権利情報
-
- http://creativecommons.org/licenses/by-nc-nd/3.0/
- DOI
-
- 10.2337/db13-0663
- 公開者
- American Diabetes Association
この論文をさがす
説明
<jats:p>Experiments in animals suggest that the neuropeptide oxytocin acts as an anorexigenic signal in the central nervous control of food intake. In humans, however, research has almost exclusively focused on the involvement of oxytocin in the regulation of social behavior. We investigated the effect of intranasal oxytocin on ingestion and metabolic function in healthy men. Food intake in the fasted state was examined 45 min after neuropeptide administration, followed by the assessment of olfaction and reward-driven snack intake in the absence of hunger. Energy expenditure was registered by indirect calorimetry, and blood was repeatedly sampled to determine concentrations of blood glucose and hormones. Oxytocin markedly reduced snack consumption, restraining, in particular, the intake of chocolate cookies by 25%. Oxytocin, moreover, attenuated basal and postprandial levels of adrenocorticotropic hormone and cortisol and curbed the meal-related rise in plasma glucose. Energy expenditure and hunger-driven food intake as well as olfactory function were not affected. Our results indicate that oxytocin, beyond its role in social bonding, regulates nonhomeostatic, reward-related energy intake, hypothalamic-pituitary-adrenal axis activity, and the glucoregulatory response to food intake in humans. These effects can be assumed to converge with the psychosocial function of oxytocin and imply possible applications in the treatment of metabolic disorders.</jats:p>
収録刊行物
-
- Diabetes
-
Diabetes 62 (10), 3418-3425, 2013-09-17
American Diabetes Association
