<b>T‐cell lymphoma in Hashimoto’s thyroiditis</b>

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書誌事項

公開日
1996-11
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1046/j.1365-2559.1996.d01-515.x
公開者
Wiley

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説明

<jats:p>An elderly Caucasian woman with a 2‐year‐history of hypothyroidism, treated with thyroxine, presented with a rapidly growing mass in the thyroid. The morphological and immunological features of this thyroid tumour were those of a peripheral T‐cell lymphoma with an immunophenotype commonly associated with HTLV‐1 positive‐adult T‐cell leukaemia/lymphoma, although serology for HTLV1 antibody was negative. Monoclonal gene rearrangements were demonstrated with T‐cell receptor beta‐ and gamma‐specific primers. There are several interesting features in this case (i): although primary B‐cell lymphomas (MALT‐associated lymphomas) of thyroid are a well‐recognized sequel to thyroiditis, primary T‐cell lymphomas are rare, even in areas of the world where adult T‐cell lymphomas predominate; (ii) the tumour showed the typical immunophenotype of an HTLV‐1 positive T‐cell lymphoma but the patient is English, has not visited endemic areas, and is serologically negative for HTLV–1; (iii) the residual thyroid gland showed a florid lymphocytic thyroiditis with Hu¨rthle cell change, typical of Hashimoto’s thyroiditis; (iv) unlike other reports of thyroid T‐cell lymphoma, which have presented with stage III‐IV disease, this tumour presented in the favourable clinical stage of IE.</jats:p>

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