Cell sheet engineering: a unique nanotechnology for scaffold‐free tissue reconstruction with clinical applications in regenerative medicine
書誌事項
- 公開日
- 2009-12-11
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/j.1365-2796.2009.02185.x
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract.</jats:title><jats:p>Cell sheet technology (CST) is based on the use of thermoresponsive polymers, poly(N‐isopropylacrylamide) (PIPAAm). The surface of PIPAAms is formulated in such a way as to make its typical thickness <100 nm. In this review, we first focus on how the methods of PIPAAm‐grafted surface preparations and functionalization are important to be able to harvest a functional cell sheet, to be further transplanted. Then, we present aspects of tissue mimics and three‐dimensional reconstruction of a tissue <jats:italic>in vitro</jats:italic>. Finally, we give an overview of clinical applications and clinically relevant animal experimentations of the technology, such as cardiomyopathy, visual acuity, periodonty, oesophageal ulcerations and type 1 diabetes.</jats:p>
収録刊行物
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- Journal of Internal Medicine
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Journal of Internal Medicine 267 (1), 54-70, 2009-12-11
Wiley
