Identification of toxS, a regulatory gene whose product enhances toxR-mediated activation of the cholera toxin promoter

DOI Web Site 被引用文献7件
  • V L Miller
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115.
  • V J DiRita
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115.
  • J J Mekalanos
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115.

書誌事項

公開日
1989-03
権利情報
  • https://journals.asm.org/non-commercial-tdm-license
DOI
  • 10.1128/jb.171.3.1288-1293.1989
公開者
American Society for Microbiology

この論文をさがす

説明

<jats:p>We describe the cloning of the toxS gene from Vibrio cholerae E1 Tor strain E7946. This gene lies downstream from the toxR gene, which encodes the transcriptional activator for the cholera toxin (ctx) operon in V. cholerae. We show that ToxS acts in conjunction with ToxR to activate expression of the ctx operon in Escherichia coli. The classical strain 569B, which is attenuated for virulance but which synthesizes high levels of cholera toxin in vitro, carries a deletion of 1.2 kilobase pairs of DNA, downstream from the toxR gene, which removes toxS. We present evidence that toxS is the downstream gene in an operon with toxR.</jats:p>

収録刊行物

被引用文献 (7)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ