X-ray Diffraction Analysis of the .BETA.-Crystallite Assembly of Alzheimer .BETA.-Amyloid Protein Analogue.
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- INOUYE Hideyo
- ハーバード大学医学部小児病院
Bibliographic Information
- Other Title
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- Alzheimer βアミロイド蛋白アナログのX線構造解析 β結晶の集合
- Alzheimer ベータ アミロイド タンパク アナログ ノ Xセン コウゾ
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Abstract
Major proteinacious component in the Alzheimer amyloid plaque is β amyloid protein. The amino-acid sequence of this protein is:<BR>Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-lle-Ala-Thr. Among the analogues studied the residues 11-28 showed well-oriented cross β fiber pattern where wide angle reflections could be indexed by an orthogonal lattice having unit cell dimensions a=9.44Å, b=6.92Å and c=10.76Å. The intensity maxima on the equator as well as on higher layer lines were sampled by a larger period (63Å), indicating that the β crystallites constitute higher assembly. The structure was modeled as a tube where 5 beta crystallites constitute the wall.
Journal
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- Nihon Kessho Gakkaishi
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Nihon Kessho Gakkaishi 35 (5), 347-351, 1993
The Crystallographic Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204085896704
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- NII Article ID
- 130000788578
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- NII Book ID
- AN00188364
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- ISSN
- 18845576
- 03694585
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- NDL BIB ID
- 3847541
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed