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- 井上 秀世
- ハーバード大学医学部小児病院
書誌事項
- タイトル別名
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- X-ray Diffraction Analysis of the .BETA.-Crystallite Assembly of Alzheimer .BETA.-Amyloid Protein Analogue.
- Alzheimer ベータ アミロイド タンパク アナログ ノ Xセン コウゾ
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抄録
Major proteinacious component in the Alzheimer amyloid plaque is β amyloid protein. The amino-acid sequence of this protein is:<BR>Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-lle-Ala-Thr. Among the analogues studied the residues 11-28 showed well-oriented cross β fiber pattern where wide angle reflections could be indexed by an orthogonal lattice having unit cell dimensions a=9.44Å, b=6.92Å and c=10.76Å. The intensity maxima on the equator as well as on higher layer lines were sampled by a larger period (63Å), indicating that the β crystallites constitute higher assembly. The structure was modeled as a tube where 5 beta crystallites constitute the wall.
収録刊行物
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- 日本結晶学会誌
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日本結晶学会誌 35 (5), 347-351, 1993
日本結晶学会
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詳細情報 詳細情報について
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- CRID
- 1390001204085896704
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- NII論文ID
- 130000788578
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- NII書誌ID
- AN00188364
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- ISSN
- 18845576
- 03694585
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- NDL書誌ID
- 3847541
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可