書誌事項
- タイトル別名
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- An Insight into the Mechanism of Enzymatic Reaction on Aminoacyl-tRNA Synthetases
- アミノアシル-tRNA合成酵素の酵素反応機構に関する研究
- アミノアシル tRNA ゴウセイ コウソ ノ コウソ ハンノウ キコウ ニ カンスル ケンキュウ
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The mechanism that ATP-pyrophosphate exchange reaction catalyzed by Arg-tRNA, Gln-tRNA and Glu-tRNA synthetases requires assistance of the cognate tRNA, remained to be established. On the basis of crystal structure of Arg-tRNA synthetase from Pyrococcus horikoshii complexed with tRNAArgCCU and ATP analog, we constructed a structural model for a mechanism in which formation of a hydrogen bond between 2’-OH group of A76 of tRNA and carboxyl group of Arg induces both formation reaction of Arg-AMP from Arg and ATP and the reverse reaction pyrophosphorolysis at low pH. The hydrogen bond assists also editing of misacylated Thr-tRNAVAl or Thr-AMP bound Val-tRNA synthetase.
収録刊行物
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- 日本結晶学会誌
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日本結晶学会誌 52 (2), 125-132, 2010
日本結晶学会
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詳細情報 詳細情報について
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- CRID
- 1390001204087105792
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- NII論文ID
- 10026402462
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- NII書誌ID
- AN00188364
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- COI
- 1:CAS:528:DC%2BC3cXntVGlsro%3D
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- ISSN
- 18845576
- 03694585
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- NDL書誌ID
- 10691883
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可