書誌事項
- タイトル別名
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- A Novel Mode of Target Recognition Suggested by the 2.0 .ANGS. Structure of Holo S 100B from Bovine Brain.
- サイキン ノ ケンキュウ カラ Ca2 ケツゴウ タンパクシツ S100B ノ ケッショウ コウゾウ ト ブンシ ニンシキ キコウ
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The three-dimensional structure of holo S100B from bovine brain has been determined at 2.0 Å resolution by X-ray diffraction. The dimeric S100B molecule is formed by non-covalent interactions between large hydrophobic surface on both S100β subunits. There are two EF-hand motifs per S100β subunit, each of which binds one calcium ion. We observe, in the calcium-bound structure, dramatic changes in the conformation of the terminal helices, from the compact structure in the apo form to a more extended form upon binding calcium. This conformational change suggests a novel mode of target recognition of S100B.
収録刊行物
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- 日本結晶学会誌
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日本結晶学会誌 41 (6), 347-352, 1999
日本結晶学会
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詳細情報 詳細情報について
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- CRID
- 1390001204087488512
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- NII論文ID
- 10004674054
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- NII書誌ID
- AN00188364
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- ISSN
- 18845576
- 03694585
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- NDL書誌ID
- 4987826
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可