<I>Trans</I>-アネトール誘導体と数種のモノテルペニル化合物との縮合反応ならびにチロシナーゼ活性阻害, 活性酸素抑制効果およびヒアルロニダーゼ活性阻害について
書誌事項
- タイトル別名
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- Condensation Reaction of <I>Trans</I>-Anethole Derivatives with Several Monoterpenyl Compounds and Their Inhibition Properties towards Tyrosinase, Superoxide Scavenging Activity and Hyaluronidase Activity
- Trans アネトール ユウドウタイ ト スウシュ ノ モノテルペニル カゴウブツ ト ノ シュクゴウ ハンノウ ナラビニ チロシナーゼ カッセイ ソガイ カッセイ サンソ ヨクセイ コウカ オヨビ ヒアルロニダーゼ カッセイ ソガイ ニ ツイテ
- 生理活性物質の合成に関する研究 (第22報)
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説明
Natural material extracts are presently used as cosmetic ingredients. Physiological effects were examined, using trans-anethole (1) from Foeniculum vnlgar MILL as starting material. Eight derivatives were synthesized by oximation (N, N-diethyl hydrazonation, methylation and elimination reaction), LiAlH4 mediated reaction, with chloroacetyl chloride and condensation with four terpenyl amines to confirm efficiency as whitening agents, inhibitory activities towards tyrosinase, superoxide scavenging activity or hyaluronidase activity. Compounds (9a), (9b) and (9c) derived from (4) were found to be inhibited by ca. 5561% in tyrosinase (Dopa) activity. The inhibitory rates exceeded that of arbutin used for commercial cosmetics (Arbutin), (9c) or (10b), and the superoxide scavenging activity was noted to be inhibited by more than ca. 33%.
収録刊行物
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- 日本油化学会誌
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日本油化学会誌 49 (2), 143-149,181, 2000
公益社団法人 日本油化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204090947200
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- NII論文ID
- 10005364571
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- NII書誌ID
- AN10512582
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- ISSN
- 18841996
- 13418327
- http://id.crossref.org/issn/13458957
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- NDL書誌ID
- 5277653
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