日本人の血清コレステロール濃度に対する植物コレステロールの最小有効量およびマヨネーズに融合した植物コレステロールの安全性評価(原標題は英語)
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- MATSUOKA Ryosuke
- R&D Division, Q.P. Corporation
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- MASUDA Yasunobu
- R&D Division, Q.P. Corporation
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- TAKEUCHI Ayako
- R&D Division, Q.P. Corporation
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- MARUSHIMA Ranko
- R&D Division, Q.P. Corporation
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- ONUKI Manabu
- Department of Neurology, Saitama Medical Center
書誌事項
- タイトル別名
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- Minimal Effective Dose of Plant Sterol on Serum Cholesterol Concentration in Japanese Subjects and Safety Evaluation of Plant Sterol Supplemented in Mayonnaise
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抄録
For examination of the title parameters, study was made in which forty healthy male subjects (serum cholesterol concentration 170-309 mg/dL) were fed 0, 200, 400, 600, or 800 mg/day of free plant sterol supplemented in mayonnaise for 4 consecutive weeks. Only the 800 mg/day group significantly reduced serum cholesterol by the paired t-test (Exp.1). Thirty-two healthy males (serum cholesterol, 184-285 mg/dL) were made to consume plant sterol as ester at 0, 800, 1600, or 2400 mg/day. In all cases at more than 800 mg/day reduction in serum cholesterol was noted though without significant difference with paired t-test results (Exp.2). Subsequent to the mayonnaise consumption, normal diets were resumed for a period of 4 weeks. Total cholesterol showed original values at the end of this period. Plant sterol is thus shown to be a dietary component capable of reducing cholesterol by these results. Fifteen healthy subjects (males 10, females 5) were made to consume free plant sterol supplemented in mayonnaise at 2400 mg/day for 4 consecutive weeks. No change in serum vitamin A or vitamin E levels was observed at 2400 mg consumption. At 2400 mg, a significant increase in serum β-sitosterol was noted though it was markedly less than β-sitosterolemia. Clinical trial results, in all cases, were normal (Exp.3). The minimal effective dose of plant sterol on serum cholesterol concentration would thus appear to be 800 mg/day. At 2400 mg/day in mayonnaise, physiological and biochemical safety markers in serum would not undergo abnormal change.
収録刊行物
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- Journal of Oleo Science
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Journal of Oleo Science 53 (1), 17-27, 2004
公益社団法人 日本油化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204091067008
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- NII論文ID
- 130004435944
- 10011821891
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- NII書誌ID
- AA11503337
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- ISSN
- 13473352
- 13458957
- http://id.crossref.org/issn/13458957
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- NDL書誌ID
- 6787010
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可