Effects of Lysophospholipids on Hyaluronic Acid Synthesis in the Skin. II.

TANAKA Shinji, HASHIZUME Ron, DOI Hiroshi, YAMAMOTO Noboru

doi:10.5650/jos1996.46.977

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Other Title

リゾリン脂質による皮膚のヒアルロン酸産生促進効果 (第2報)
リゾリンシシツニヨルヒフノヒアルロンサンサンセイソクシンコウ
Effects of Lysophosphatidylcholine on the Cell Proliferation of Cultured Dermal Fibroblasts
培養真皮線維芽細胞の細胞増殖に対するリゾホスファチジルコリンの影響

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Naturally occurring lysophosphatidylcholine (LPC) has effect on many different cell proesses, such as monocyte chemotaxis, smooth muscle cell contraction, platelet activation and the secretion of growth factors from endothelial cells. In this study, examination was made of the effects of exogenous LPC on DNA synthesis in human dermal fibroblasts, NB1RGB. DNA synthesis was accelerated by C_{12 : 0}-, C_{14 : 1}- and C_{16 : 1}-LPC, all of which were previously shown to enhance the synthesis of glycosaminoglycan (GAG, mainly hyaluronic acid). C_{18 : 3}-L, PC possessing activity for GAG synthesis greatly repressed that of DNA. DNA synthesis enhanced by C_{12 : 0}-LPC failed to occur due to the presence together of staruosporine, genistein, islet-activating protein (IAP) and propranolol. Neither was there any GAG synthesis which had been enhanced by C_{12 : 0}-LPC and C_{18 : 3}-LPC, due to these inhibitors except for propranolol. Phosphatidylethanol had no effect either on DNA or GAG synthesis. Depressed DNA synthesis by C_{18 : 3}-LPC was not restored by IAP. The activation of adenylyl cyclase would thus appear unrelated to the depression of DNA synthesis.

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Journal of Japan Oil Chemists' Society

Journal of Japan Oil Chemists' Society 46 (9), 977-984,1029, 1997

Japan Oil Chemists' Society

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