リゾリン脂質による皮膚のヒアルロン酸産生促進効果 (第2報)

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タイトル別名
  • Effects of Lysophospholipids on Hyaluronic Acid Synthesis in the Skin. II.
  • リゾ リン シシツ ニヨル ヒフ ノ ヒアルロンサン サンセイ ソクシン コウ
  • Effects of Lysophosphatidylcholine on the Cell Proliferation of Cultured Dermal Fibroblasts
  • 培養真皮線維芽細胞の細胞増殖に対するリゾホスファチジルコリンの影響

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説明

Naturally occurring lysophosphatidylcholine (LPC) has effect on many different cell proesses, such as monocyte chemotaxis, smooth muscle cell contraction, platelet activation and the secretion of growth factors from endothelial cells. In this study, examination was made of the effects of exogenous LPC on DNA synthesis in human dermal fibroblasts, NB1RGB. DNA synthesis was accelerated by C12 : 0-, C14 : 1- and C16 : 1-LPC, all of which were previously shown to enhance the synthesis of glycosaminoglycan (GAG, mainly hyaluronic acid). C18 : 3-L, PC possessing activity for GAG synthesis greatly repressed that of DNA. DNA synthesis enhanced by C12 : 0-LPC failed to occur due to the presence together of staruosporine, genistein, islet-activating protein (IAP) and propranolol. Neither was there any GAG synthesis which had been enhanced by C12 : 0-LPC and C18 : 3-LPC, due to these inhibitors except for propranolol. Phosphatidylethanol had no effect either on DNA or GAG synthesis. Depressed DNA synthesis by C18 : 3-LPC was not restored by IAP. The activation of adenylyl cyclase would thus appear unrelated to the depression of DNA synthesis.

収録刊行物

  • 日本油化学会誌

    日本油化学会誌 46 (9), 977-984,1029, 1997

    公益社団法人 日本油化学会

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