Sirtuin A regulates secondary metabolite production by Aspergillus nidulans
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- Itoh Eriko
- Faculty of Life and Environmental Sciences, University of Tsukuba
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- Shigemoto Ryosuke
- Faculty of Life and Environmental Sciences, University of Tsukuba
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- Oinuma Ken-Ichi
- Faculty of Life and Environmental Sciences, University of Tsukuba
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- Shimizu Motoyuki
- Faculty of Life and Environmental Sciences, University of Tsukuba
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- Masuo Shunsuke
- Faculty of Life and Environmental Sciences, University of Tsukuba
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- Takaya Naoki
- Faculty of Life and Environmental Sciences, University of Tsukuba
書誌事項
- タイトル別名
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- Sirtuin A regulates secondary metabolite production by <i>Aspergillus nidulans</i>
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説明
<p>Late-stage cultures of filamentous fungi under nutrient starvation produce valuable secondary metabolites such as pharmaceuticals and pigments, as well as deleterious mycotoxins, all of which have remarkable structural diversity and wide-spectrum bioactivity. The fungal mechanisms regulating the synthesis of many of these compounds are not fully understood, but sirtuin A (SirA) is a key factor that initiates production of the secondary metabolites, sterigmatocystin and penicillin G, by Aspergillus nidulans. Sirtuin is a ubiquitous NAD+-dependent histone deacetylase that converts euchromatin to heterochromatin and silences gene expression. In this study, we have investigated the transcriptome of a sirA gene disruptant (SirAΔ), and found that SirA concomitantly repressed the expression of gene clusters for synthesizing secondary metabolites and activated that of others. Extracts of SirAΔ cultures grown on solid agar and analyzed by HPLC indicated that SirA represses the production of austinol, dehydroaustinol and sterigmatocystin. These results indicated that SirA is a transcriptional regulator of fungal secondary metabolism.</p>
収録刊行物
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- The Journal of General and Applied Microbiology
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The Journal of General and Applied Microbiology 63 (4), 228-235, 2017
公益財団法人 応用微生物学・分子細胞生物学研究奨励会
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詳細情報 詳細情報について
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- CRID
- 1390001204145345152
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- NII論文ID
- 130006067742
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- NII書誌ID
- AA00698664
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- ISSN
- 13498037
- 00221260
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- HANDLE
- 2241/00148410
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- PubMed
- 28674377
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可