Production of new anthracycline antibiotics 1-hydroxyoxaunomycin and 6-deoxyoxaunomycine by limited biosynthetic conversion using a daunorubicin-negative mutant.
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- YOSHIMOTO AKIHIRO
- Central Research Laboratories, Mercian Corporation Present address: Laboratories for Microbial Biochemistory, Faculty of Applied Biological Science, Hiroshima University
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- JOHDO OSAMU
- Central Research Laboratories, Mercian Corporation
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- TONE HIROSHI
- Central Research Laboratories, Mercian Corporation
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- OKAMOTO ROKUROU
- Central Research Laboratories, Mercian Corporation
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- NAGANAWA HIROSHI
- Institute of Microbial Chemistry
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- SAWA TSUTOMU
- Institute of Microbial Chemistry
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- TAKEUCHI TOMIO
- Institute of Microbial Chemistry
抄録
A limited biosynthetic conversion of some known anthracyclinones using a specific daunorubicin-nonproducing mutant provided four new anthracycline antibiotics: 1-Hydroxy-10-methoxycarbonyl-13-deoxocarminomycin; 1-hydroxy-13-deoxocarminomycin; 1-hydroxyoxaunomycin and 6-deoxyoxaunomycin. Their isolation and purification from bioconversion broth, structural determination and antitumor activities against leukemic L1210 cells are described.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 45 (10), 1609-1617, 1992
公益財団法人 日本感染症医薬品協会