Cochinmicins, novel and potent cyclodepsipeptide endothelin antagonists from a Microbispora sp. I. Production, isolation, and characterization.
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- LAM Y. K. TONY
- Merck Research Laboratories
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- WILLIAMS DAVID L.
- West Point
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- SIGMUND JANET M.
- Merck Research Laboratories
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- SANCHEZ MANUEL
- Merck Sharp and Dohme De EspaÑa, S.A.
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- GENILLOUD OLGA
- Merck Sharp and Dohme De EspaÑa, S.A.
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- KONG YU L.
- Merck Research Laboratories
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- STEVENS-MILES SIOBHAN
- Merck Research Laboratories
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- HUANG LEEYUAN
- Merck Research Laboratories
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- GARRITY GEORGE M.
- Merck Research Laboratories
Bibliographic Information
- Other Title
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- Cochinmicins novel and potent cyclodepsipeptide endothelin antagonists from a Microbispora sp
- I. PRODUCTION, ISOLATION, AND CHARACTERIZATION
Description
Cochinmicins I, II, III are novel peptolides produced in submerged-fermentation cultures of Microbispora sp. ATCC 55140. These closely related compounds are separated by HPLC and are novel competitive endothelin antagonists. Cochinmicins II and III are stereoisomeric to each other. Cochinmicin I is the deschloro analog of cochinmicin III.
Journal
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- The Journal of Antibiotics
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The Journal of Antibiotics 45 (11), 1709-1716, 1992
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
