Cochinmicins novel and potent cyclodepsipeptide endothelin antagonists from a Microbispora sp
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- LAM Y. K. TONY
- Merck Research Laboratories
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- WILLIAMS DAVID L.
- West Point
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- SIGMUND JANET M.
- Merck Research Laboratories
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- SANCHEZ MANUEL
- Merck Sharp and Dohme De EspaÑa, S.A.
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- GENILLOUD OLGA
- Merck Sharp and Dohme De EspaÑa, S.A.
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- KONG YU L.
- Merck Research Laboratories
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- STEVENS-MILES SIOBHAN
- Merck Research Laboratories
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- HUANG LEEYUAN
- Merck Research Laboratories
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- GARRITY GEORGE M.
- Merck Research Laboratories
書誌事項
- タイトル別名
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- Cochinmicins, novel and potent cyclodepsipeptide endothelin antagonists from a Microbispora sp. I. Production, isolation, and characterization.
- I. PRODUCTION, ISOLATION, AND CHARACTERIZATION
説明
Cochinmicins I, II, III are novel peptolides produced in submerged-fermentation cultures of Microbispora sp. ATCC 55140. These closely related compounds are separated by HPLC and are novel competitive endothelin antagonists. Cochinmicins II and III are stereoisomeric to each other. Cochinmicin I is the deschloro analog of cochinmicin III.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 45 (11), 1709-1716, 1992
公益財団法人 日本感染症医薬品協会
