Megalomicin,a new macrolide antibiotic complex produced by Micromonospora

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  • MEGALOMICIN, A NEW MACROLIDE ANTIBIOTIC COMPLEX PRODUCED BY <i>MICROMONOSPORA</i>

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A new macrolide antibiotic complex has been isolated from fermentation broths of two strains of a news pecies of Micromonospora, M. megalomicea sp. n. The antibiotic complex has been differentiated from other known macrolides and methods for its production, isolation and separation of components have been devised. Like other macrolides, it is primarily active against gram-positive bacteria and is more active at an alkaline pH. Of the four known components, megalomicin A has been studied most extensively. It has activity equal to or slightly less than that of erythromycin both in vitro and in vivo. In dogs dosed orally, it is better tolerated and gives higher peak serum levels with a much greater duration than erythromycin.

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