Interactions between bleomycins and metals.

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  • Interactions between bleomycins and met

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Gel filtration has shown that there are considerable differences between the metal complexes of bleomycin A2 and B2 with indium, cobalt or copper. Differences in the rates of formation of the complexes have also been found and it is thought that these effects are due to a difference<br>in co-ordination between the metals and the bleomycin. The co-ordination changes are thought to be the cause of the differences in in vivo distribution of metal bleomycin complexes found in the radiodiagnosis of tumours. The ease of formation of the copper or cobalt complexes is suggested as a possible mechanism for the inhibition of the attack of DNA by bleomycins.

収録刊行物

  • The Journal of Antibiotics

    The Journal of Antibiotics 29 (10), 1102-1108, 1976

    公益財団法人 日本感染症医薬品協会

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