キャピラリガスクロマトグラフィを用いた同位体希釈分析による患者尿中フェンタニルおよび主代謝物ノルフェンタニルの定量

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  • Isotope Dilution Analysis for Urinary Fentanyl and Its Main Metabolite, Norfentanyl, in Patients by Isotopic Fractionation Using Capillary Gas Chromatography.
  • Isotope Dilution Analysis for Urinary F

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Isotope dilution analysis was applied to determine urinary excretion of fentanyl (FT) and its main metabolite, norfentanyl (Nor-FT), by isotopic fractionation using a capillary gas chromatograph equipped with a surface ionization detector (SID) . Urinary FT was determined quantitatively in the range of 0.4-40 ng/ml using deuterium labeled FT (FT-2H19), as an internal standard.<BR>We also performed isotope dilution analysis of Nor-FT in urine. NV Alkylation was necessary to sensitively detect Nor-FT with SID. Methyl derivative was selected from 3 kinds of NV alkyl derivatives to increase sensitivity and peak resolution, and to prevent interference with urinary compound. Nor-FT concentration was quantitatively determined in the range of 10-400 ng/ml using deuterium labeled Nor-FT (Nor-FT-2H10) . No endogenous compounds or concomitant drugs interfered with the detection of FT and Nor-FT in the urine of patients. The present method will be useful for pharmacokinetic studies and the evaluation of drug interactions in FT metabolism.

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