書誌事項
- タイトル別名
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- Isotope Dilution Analysis for Urinary Fentanyl and Its Main Metabolite, Norfentanyl, in Patients by Isotopic Fractionation Using Capillary Gas Chromatography.
- Isotope Dilution Analysis for Urinary F
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Isotope dilution analysis was applied to determine urinary excretion of fentanyl (FT) and its main metabolite, norfentanyl (Nor-FT), by isotopic fractionation using a capillary gas chromatograph equipped with a surface ionization detector (SID) . Urinary FT was determined quantitatively in the range of 0.4-40 ng/ml using deuterium labeled FT (FT-2H19), as an internal standard.<BR>We also performed isotope dilution analysis of Nor-FT in urine. NV Alkylation was necessary to sensitively detect Nor-FT with SID. Methyl derivative was selected from 3 kinds of NV alkyl derivatives to increase sensitivity and peak resolution, and to prevent interference with urinary compound. Nor-FT concentration was quantitatively determined in the range of 10-400 ng/ml using deuterium labeled Nor-FT (Nor-FT-2H10) . No endogenous compounds or concomitant drugs interfered with the detection of FT and Nor-FT in the urine of patients. The present method will be useful for pharmacokinetic studies and the evaluation of drug interactions in FT metabolism.
収録刊行物
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- RADIOISOTOPES
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RADIOISOTOPES 47 (7), 537-545, 1998
公益社団法人 日本アイソトープ協会
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詳細情報 詳細情報について
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- CRID
- 1390001204154815232
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- NII論文ID
- 130004383120
- 10002388671
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- NII書誌ID
- AN00351589
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- ISSN
- 18844111
- 00338303
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- NDL書誌ID
- 4521975
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可