周期律第II族元素のがんおよび臓器親和性の研究

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  • Study of Affinity for a Malignant Tumor and Organs of the Elements in Group ll of the Periodic Table
  • シュウキ リツ ダイ2ゾク ゲンソ ノ ガン オヨビ ゾウキ シンワセイ ノ ケンキュウ

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Seven preparations, 115mCd-chloride, 115mCd-citrate, 115mCd-EDTA, 65Zn-chloride, 85Sr-chloride, 85Sr-citrate and 85Sr-EDTA were injected intravenously to each group of rats transplanted subcutaneously with Yoshida sarcoma. These rats were sacrificed at various periods after injection of each preparation: 3 hours, 24 hours and 48 hours in 115mCd-chloride and 115mCd-citrate, 3 hours and 24 hours in 115mCd-EDTA and 65Zn-chloride, 15 minutes, 3 hours and 24 hours in 85Sr-citrate, 15 minutes and 24 hours in 85Sr-chloride and 85Sr-EDTA. The radioactivities of tumor, blood, muscle, liver, kidney, pancreas and spleen were measured by a well-type scintillation counter, and retention values in every tissue including tumor were calculated (in per cent of administered dose per g-tissue weight) .<BR>115mCd-chloride, 115mCd-citrate and 65Zn-chloride had very strong affinity for the liver and considerably strong affinity for the pancreas and kidney. 115mCd-EDTA had considerably strong affinity for the kidney and liver, but had not affinity for the iancreas. 115mCd- and 65Zn-compounds had little affinity for the malignant tumor. 85Sr-compounds were rapidly cleared from these organs, but clearance of 85Sr-compounds in tumor were slower than the other organs.<BR>Cd, Zn and Sr (the elements in group II of the periodic table) had little affinity for the malignant tumor.

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