書誌事項
- タイトル別名
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- Evaluation of Stat Assay of Serum Digoxin Concentration by Radioimmunoassay and Its Application for Digoxin Regimen Based on Pharmacokinetics
- ラジオイムノアッセイ ニヨル ケッセイ ジゴキシン ノウド ノ ソクテイ ジン
- ―迅速測定法の検討と薬物動態理論に基づく治療設計への応用―
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抄録
Serum digoxin concentrations measured by stat RIA (phadebas digoxin RIA kit) correlated well with results obtained by complete assays. The result of stat assay can be reported within 1 hour, measuring one or more samples together with 2 standard samples in duplicates. Precise measurement can be expected with serum digoxin concentration over 0.5 ng/ml.<BR>The stat assay allows to apply the theory of pharmacokinetics for the estimation of digoxin concentration at steady states measuring minimum digoxin concentration (Cn (min) ) on the 3rd to 6th day after the start of digoxin therapy. The estimated serum digoxin levels were well agreed with measured values with the difference ranging from Y.6 to 8.6% in CV.<BR>The method is usefull for the planning and assessment of appropriate digoxin regimen.
収録刊行物
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- RADIOISOTOPES
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RADIOISOTOPES 29 (9), 432-437, 1980
公益社団法人 日本アイソトープ協会
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詳細情報 詳細情報について
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- CRID
- 1390001204156422656
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- NII論文ID
- 130004381262
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- NII書誌ID
- AN00351589
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- ISSN
- 18844111
- 00338303
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- NDL書誌ID
- 2191090
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- PubMed
- 7221021
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可