Antitumor-Promoting Constituents from Chaenomeles sinensis KOEHNE and Their Activities in JB6 Mouse Epidermal Cells
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- Gao Huiyuan
- Department of Traditional Chinese Medicines, Shenyang Pharmaceutical University
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- Wu Lijun
- Department of Traditional Chinese Medicines, Shenyang Pharmaceutical University
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- Kuroyanagi Masanori
- School of Bioresources, Hiroshima Prefectural University
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- Harada Kazunori
- School of Bioresources, Hiroshima Prefectural University
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- Kawahara Nobuo
- National Institute of Health Sciences, Japan
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- Nakane Takahisa
- Tsukuba Medicinal Plant Station, National Institute of Health Sciences, Japan
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- Umehara Kaoru
- School of Pharmaceutical Sciences, University of Shizuoka
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- Hirasawa Ayako
- School of Pharmaceutical Sciences, University of Shizuoka
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- Nakamura Yoshiyuki
- School of Pharmaceutical Sciences, University of Shizuoka
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説明
Primary screening of antitumor-promoting activity using soft agar colony assays with JB6 cells was employed to isolate 22 compounds from Chaenomeles sinensis KOEHNE. These compounds were lyoniresinol-2a-O-α-L-rhamnopyranoside (1), lyoniresinol-2a-O-β-D-glucopyranoside (2), aviculin (3), betulinic acid (4), betulin (5), 3-O-(E)-p-coumaroylbetulin (6), 3-O-(E)-caffeoylbetulin (7), 3-O-(Z)-p-coumaroylbetulin (8), 3-O-(E)-caffeoyllupeol (9), alphitolic acid (10), sorbikortal II (11), tormentic acid (12), euscaphic acid (13), corosolic acid (14), maslinic acid (15), erythrodiol (16), 1-β-D-glucopyranosyloxy-3,4,5-trimethoxybenzene (17), avicularin (18), 7-O-β-D-glucopyranosylkaempferol (19), 5-O-β-D-glucopyranosylgenistein (20), 7-O-β-D-glucopyranosylgenistein (21), epicatechin (22), and β-sitosterol (23) and were identified using spectral data such as MS, 1H- and 13C-NMR. Compound 1, having a rhamnosyl group, showed greater activity than 2, having a glucosyl group, and 3, which was a bis-demethoxy derivative of 1. Betulinic acid (4), having a C-28 carboxyl group, 3-O-(E)-caffeoylbetulin (7), and tormentic acid (12) showed more potent activity than betulin (5), which has a C-28 hydroxymethyl group.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 51 (11), 1318-1321, 2003
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204166611712
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- NII論文ID
- 110003615212
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
- http://id.crossref.org/issn/03851605
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- NDL書誌ID
- 6723360
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- PubMed
- 14600382
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- 本文言語コード
- en
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- 資料種別
- journal article
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- PubMed
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