Bioactive Constituents from Chinese Natural Medicines(20)Inhibitors of Antigen-Induced Degranulation in RBL-2H3 Cells from the Seeds of Psoralea corylifolia
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- Matsuda Hisashi
- Kyoto Pharmaceutical University
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- Sugimoto Sachiko
- Kyoto Pharmaceutical University
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- Morikawa Toshio
- Kyoto Pharmaceutical University Pharmaceutical Research and Technology Institute, Kinki University
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- Matsuhira Koudai
- Kyoto Pharmaceutical University
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- Mizuguchi Eri
- Kyoto Pharmaceutical University
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- Nakamura Seikou
- Kyoto Pharmaceutical University
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- Yoshikawa Masayuki
- Kyoto Pharmaceutical University
書誌事項
- タイトル別名
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- Bioactive Constituents from Chinese Natural Medicines. XX. Inhibitors of Antigen-Induced Degranulation in RBL-2H3 Cells from the Seeds of <i>Psoralea corylifolia</i>
- Bioactive constituents from Chinese natural medicines. XX. Inhibition of antigen-induced degranulation in RBL-2H3 cells from the seeds of Psoralea corylifolia
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The ethyl acetate-soluble fraction of the methanolic extract from the seeds of Psoralea corylifolia was found to inhibit the release of β-hexosaminidase, as a marker of antigen-IgE-induced degranulation in RBL-2H3 cells. Sixteen constituents were isolated from the ethyl acetate-soluble fraction and several constituents, Δ1,3-hydroxybakuchiol (IC50=49 μM), Δ3,2-hydroxybakuchiol (69 μM, bavachin (58 μM), and psoralidin (ca. 100 μM), showed inhibitory activities against the antigen-induced degranulation.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 55 (1), 106-110, 2007
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204170268288
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- NII論文ID
- 110006151443
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 8588930
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可
