L-.BETA.-(5-Hydroxy-2-pyridyl)-alanine and L-.BETA.-(3-hydroxyureido)-alanine from streptomyces.
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In the course of the chemical screening study on the metabolites from actinomycetes, two unusual amino acids were isolated : L-β-(5-Hydroxy-2-pyridyl)-alanine (1) and L-β-(3-hydroxyureido)-alanine (9). The structures of 1 and 9 were elucidated from the physico-chemical properties of these amino acids and derivatives, and supported by synthesis. Antibacterial activities of 1 and its methylester (2) were antagonized by L-tyrosine, and those of 9 and its derivative (17) by L-glutamine.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 23 (11), 2669-2677, 1975
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204171451136
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- NII論文ID
- 110003621755
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- NII書誌ID
- AA00602100
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- COI
- 1:CAS:528:DyaE28XksVKgtw%3D%3D
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- ISSN
- 13475223
- 00092363
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- PubMed
- 1218439
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可