A New Diarylheptanoid Glycoside from the Stem Bark of Alnus hirsuta and Protective Effects of Diarylheptanoid Derivatives in Human HepG2 Cells
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- Park Daae
- Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University Doping Control Center, Research Coordination Division, Korea Institute of Science and Technology
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- Kim Hyoung Ja
- Bioanalysis and Biotransformation Research Center, Life Sciences Research Division, Korea Institute of Science and Technology
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- Jung Seo Yun
- Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University
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- Yook Chang-Soo
- Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University
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- Jin Changbae
- Doping Control Center, Research Coordination Division, Korea Institute of Science and Technology
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- Lee Yong Sup
- Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University
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Description
To search for secondary metabolites of Alnus hirsuta (Betulaceae), various chromatographic separations of the ethyl acetate soluble fraction of the stem bark of A. hirsuta led to the isolation of a new diarylheptanoid glycoside, (3R)-1,7-bis-(4-dihydroxyphenyl)-3-heptanol 3-O-β-D-glucopyranosyl(1→3)-β-D-xylopyranoside (13) and twelve diarylheptanoid derivatives, namely, oregonin (1), rubranoside A (2), hirsutanonol 5-O-β-D-glucopyranoside (3), rubranoside B (4), rubranoside C (5), hirsutanonol (6), hirsutenone (7), (5S)-O-methylhirsutanonol (8), platyphylloside (9), platyphyllonol 5-O-β-D-xylopyranoside (10), aceroside VII (11) and platyphyllenone (12). Isolates were assessed for their hepatoprotective effects against tert-butylhydroperoxide (t-BHP)-induced toxicity in HepG2 cells. Of these isolates, compounds 1—8 showed significant hepatoprotective effects on t-BHP-induced damage to HepG2 cells, with 8 exhibiting the greatest protective effect (50.7±3.7% at a concentration of 10 μM).
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 58 (2), 238-241, 2010
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204171738112
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- NII Article ID
- 130000161600
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 10537356
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed