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The N-alkylation of DL-trans-and DL-cis-2-aminocyclohexanols was effected with alkylating agents in the presence of potassium carbonate. When lower alkylating agents were used, the trans form gave N-dialkyl derivatives, while the cis form gave only N-monoalkyl derivatives. The use of higher alkylating agents led both forms to N-monoalkyl derivatives. The resistance of the cis form to dialkylation in the presence of the lower alkylating agents was presumably due to a hydrogen bond between the hydroxyl and the amino groups in the cis relationship. This assumption may be supported by an analogous phenomenon which was already found in the Schotten-Baumann benzoylation of diasteromeric 2, 2'-dihydroxydicyclohexylamine.2, 15)
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 11 (2), 222-225, 1963
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204171747968
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- NII論文ID
- 110003661353
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 9245153
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可