Synthesis, Biological Activity of Salidroside and Its Analogues

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  • Guo Yibing
    Jiangsu Key Laboratory of Neuroregeneration, Nantong University Medical School, Nantong University
  • Zhao Yahong
    Jiangsu Key Laboratory of Neuroregeneration, Nantong University
  • Zheng Cheng
    Institue of Nautical Medicine, Nantong University
  • Meng Ying
    Jiangsu Key Laboratory of Neuroregeneration, Nantong University
  • Yang Yumin
    Jiangsu Key Laboratory of Neuroregeneration, Nantong University

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説明

Salidroside is a phenylpropanoid glycoside isolated from Rhodiola rosea L., a traditional Chinese medicinal plant, and has displayed a broad spectrum of pharmacological properties. In this paper, about 18 novel salidroside analogues were prepared through Koenigs–Knorr method, the effects of these compounds over PC12 was assessed with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. The novel compounds differ in the substituents attached to the benzene ring or in the glycosyl donor. According to the data, compounds (3,5-dimethoxyphenyl)methyl β-D-glucopyranoside and (3,5-dimethoxyphenyl)methyl β-D-galactopyranoside with methoxy group at 3 and 5-positions of the benzene ring were the most viability at concentration of 300 μmol/l and 60 μmol/l, respectively.

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