Oppositinines A and B: new vasorelaxant β-carboline alkaloids from Neisosperma oppositifolia

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  • Ahmad Kartini
    Department of Chemistry, Faculty of Science and Technology, University Pendidikan Sultan Idris
  • Thomas Noel F.
    Department of Chemistry, Faculty of Science, University of Malaya
  • Hadi A. Hamid A.
    Department of Chemistry, Faculty of Science, University of Malaya
  • Mukhtar Mat Ropi
    Department of Chemistry, Faculty of Science, University of Malaya
  • Mohamad Khalit
    Department of Pharmacy, Faculty of Medicine, University of Malaya
  • Nafiah Mohd Azlan
    Department of Chemistry, Faculty of Science and Technology, University Pendidikan Sultan Idris
  • Takeya Koichi
    Tokyo University of Pharmacy and Life Sciences
  • Morita Hiroshi
    Faculty of Pharmaceutical Sciences, Hoshi University
  • Litaudon Marc
    Institut de Chimie des Substances Naturelles
  • Arai Hiroko
    Faculty of Pharmaceutical Sciences, Hoshi University
  • Awang Khalijah
    Department of Chemistry, Faculty of Science, University of Malaya

書誌事項

タイトル別名
  • Oppositinines A and B: New Vasorelaxant .BETA.-Carboline Alkaloids from Neisosperma oppositifolia
  • Oppositinines A and B new vasorelaxant v carboline alkaloids from Neisosperma oppositifolia

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抄録

A phytochemical study on the bark of Neisosperma oppositifolia (Apocynaceae) yielded two new β-carboline indole alkaloids, oppositinines A (1) and B (2), together with five known alkaloids, isoreserpiline, isocarapanaubine, vobasine, 10-methoxydihydrocorynantheol-N-oxide, and ochropposinine oxindole. Structural elucidation of 1 and 2 was performed using 2D NMR methods. Oppositinines A (1) and B (2) showed potent vasorelaxant effects on the rat aorta.

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