On the Reaction of 4-Quinazolinecabonitrile with Nucleophilic Reagents. IV. Reaction of 4-Quinazolinecarbonitrile with Active Methylene Compounds
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- Higashino Takeo
- Shizuoka College of Pharmacy
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Description
The reactions of 4-quinazolinecarbonitrile (I) with active methylene compounds were carried out in order to elucidate the chemical properties of (I). In the presence of sodium amide, reactions of (I) with ethyl acetoacetate, diethyl malonate, or ethyl cyanoacetate give ethyl 4-quinazolineacetate (II), and ethyl α-cyano-4-quinazolineacetate (III), respectively. In the presence of potassium carbonate, reactions of (I) with nitromethane, or nitroethane give 4-nitromethylquinazoline (IV), and 4-(1-nitroethyl) quinazoline (V), respectively. The foregoing results showed that the 4-position of (I) was very reactive to anionoid reagents, as was already demonstrated in Parts I, II, and III of this series.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 10 (11), 1052-1055, 1962
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204174425856
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- NII Article ID
- 110003618761
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- PubMed
- 13954398
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed