On the Reaction of 4-Quinazolinecabonitrile with Nucleophilic Reagents. IV. Reaction of 4-Quinazolinecarbonitrile with Active Methylene Compounds
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- 東野 武郎
- Shizuoka College of Pharmacy
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説明
The reactions of 4-quinazolinecarbonitrile (I) with active methylene compounds were carried out in order to elucidate the chemical properties of (I). In the presence of sodium amide, reactions of (I) with ethyl acetoacetate, diethyl malonate, or ethyl cyanoacetate give ethyl 4-quinazolineacetate (II), and ethyl α-cyano-4-quinazolineacetate (III), respectively. In the presence of potassium carbonate, reactions of (I) with nitromethane, or nitroethane give 4-nitromethylquinazoline (IV), and 4-(1-nitroethyl) quinazoline (V), respectively. The foregoing results showed that the 4-position of (I) was very reactive to anionoid reagents, as was already demonstrated in Parts I, II, and III of this series.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 10 (11), 1052-1055, 1962
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204174425856
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- NII論文ID
- 110003618761
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- PubMed
- 13954398
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可