Prediction of the Stability of Meropenem in Intravenous Mixtures
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- Takasu Yuko
- School of Pharmaceutical Science, Mukogawa Women’s University
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- Yoshida Miyako
- School of Pharmaceutical Science, Mukogawa Women’s University
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- Tange Mio
- School of Pharmaceutical Science, Mukogawa Women’s University
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- Asahara Keiichi
- School of Pharmaceutical Science, Mukogawa Women’s University
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- Uchida Takahiro
- School of Pharmaceutical Science, Mukogawa Women’s University
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Description
The purpose of this study was to predict the stability of meropenem in a mixed infusion. The hydrolysis of meropenem in aqueous solution was found to be accelerated by pH, and by increasing concentrations of sodium bisulfite (SBS) and L-cysteine. Equations were derived for the degradation rate constants (kobs) of pH, SBS and L-cysteine, and fractional rate constants were estimated by the nonlinear least-squares method (quasi-Newton method using the solver in Microsoft Excel) at 25°C. The activation energy (Ea) and frequency factor (A) were calculated using the Arrhenius equation. The pH of the mixed infusion was estimated using the characteristic pH curve. From these results, an equation was derived giving the residual ratio (%) of meropenem at any time after mixing an infusion containing SBS and/or L-cysteine at any temperature, and in the pH range 4.0–10.0. A high correlation was shown to exist between the estimated and determined residual ratios (%).
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 63 (4), 248-254, 2015
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001204176571776
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- NII Article ID
- 130005061426
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 026283537
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- PubMed
- 25832020
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed