Prediction of the Stability of Meropenem in Intravenous Mixtures
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- Takasu Yuko
- School of Pharmaceutical Science, Mukogawa Women’s University
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- Yoshida Miyako
- School of Pharmaceutical Science, Mukogawa Women’s University
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- Tange Mio
- School of Pharmaceutical Science, Mukogawa Women’s University
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- Asahara Keiichi
- School of Pharmaceutical Science, Mukogawa Women’s University
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- Uchida Takahiro
- School of Pharmaceutical Science, Mukogawa Women’s University
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説明
The purpose of this study was to predict the stability of meropenem in a mixed infusion. The hydrolysis of meropenem in aqueous solution was found to be accelerated by pH, and by increasing concentrations of sodium bisulfite (SBS) and L-cysteine. Equations were derived for the degradation rate constants (kobs) of pH, SBS and L-cysteine, and fractional rate constants were estimated by the nonlinear least-squares method (quasi-Newton method using the solver in Microsoft Excel) at 25°C. The activation energy (Ea) and frequency factor (A) were calculated using the Arrhenius equation. The pH of the mixed infusion was estimated using the characteristic pH curve. From these results, an equation was derived giving the residual ratio (%) of meropenem at any time after mixing an infusion containing SBS and/or L-cysteine at any temperature, and in the pH range 4.0–10.0. A high correlation was shown to exist between the estimated and determined residual ratios (%).
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 63 (4), 248-254, 2015
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204176571776
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- NII論文ID
- 130005061426
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 026283537
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- PubMed
- 25832020
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可