アスコルビン酸に由来する赤色色素のDNA損傷性と変異原性

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書誌事項

タイトル別名
  • DNA-Damaging Activity and Mutagenicity of Red-Pigment Derived from Ascorbic Acid
  • アスコルビンサン ニ ユライスル セキショク シキソ ノ DNA ソンショウセ

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抄録

Red-pigment [2, 2′-nitrilodi-2(2′)-deoxy-L-ascorbic acid monoammonium salt (NDA)] was synthesized by the reaction of dehydroascorbic acid with L-phenylalanine. The DNA-damaging activity and the mutagenicity of NDA were assayed by means of DNA-repair and two different gene mutation assays using bacteria. NDA was positive in the spore rec-assay system using Bacillus subtilis without S9 mix, showing that its DNA-damaging index was relatively weak. NDA was positive in both the Ames test and the induced mutation frequency (IMF) assay using Salmonella typhimurium strain TA100 or TA98 with or without S9 mix, revealing that the mutagenic potential was relatively weak. These results suggested that further in vivo tests should be carried out to predict whether NDA might be a carcinogenic or genetic hazard to man.

収録刊行物

  • 食品衛生学雑誌

    食品衛生学雑誌 32 (1), 13-19_1, 1991

    公益社団法人 日本食品衛生学会

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