Enhancement of the Cancer Chemotherapeutic Effect by Anticancer Agents in the Form of Fat Emulsion
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- TAKAHASHI TOSHIO
- Department of Surgery, Akita University School of Medicine
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- KONO KENICHI
- Department of Surgery, Akita University School of Medicine
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- YAMAGUCHI TOSHIHARU
- Department of Surgery, Akita University School of Medicine
書誌事項
- タイトル別名
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- Enhancement of the Cancer Chemotherapeu
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抄録
Utilizing the lipid-absorbing ability of lymphatic capillaries, anticancer agents were given in the form of fat emulsion in order to deliver them to regional lymph nodes. The emulsion, in which the drug solution is contained as the innermost phase, yielded high drug concentration in the lymphatic system. Intratumoral injection of emulsified anticancer agent resulted in significantly prolonged retension of the drug within the tumor tissue. Therapeutic experiments of the emulsion also disclosed remarkable tumor reduc-tion and cure rate as compared with aqueous solution of drugs. Oral admini-stration of emulsified 5-Fluorouracil (5-FU) was also attempted for stomach cancer. With 5-FU, the maximum concentration of drug in thoracic lymph and stomach was greater when administered as an emulsion than as an aqueous solution, and a high concentration persisted longer. As a clinical trial of the emulsion method, eight patients with inoperable malignant growth were injected locally with emulsi-fied anticancer agents and 121 patients were given 5-FU emulsion orally. From the clinical and histological findings, it was thought that the emulsion enhanced the chemotherapeutic effect of the anticancer agent on lymph node metastasis.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 123 (3), 235-246, 1977
東北ジャーナル刊行会
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詳細情報 詳細情報について
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- CRID
- 1390001204241344256
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- NII論文ID
- 130003407650
- 40005306012
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- NII書誌ID
- AA00863920
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- COI
- 1:CAS:528:DyaE1cXpsVOltw%3D%3D
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- ISSN
- 13493329
- 00408727
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- NDL書誌ID
- 1914722
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- PubMed
- 74867
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可