A Study on the Sensitivity Test of Cancer Cells to Anticancer Drugs

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For the purpose of evaluating the clinical value of ‘in vitro’ sensitivity test of cancer cells to anticancer drugs and the clinical significance of uric acid concentration in the serum and urine after cancer chemotherapy, some experiments were carried out on the DiPaolo's cell agar plate method, and the uric acid level in the serum and urine after the administration of anticancer drugs were examined.<br> In cases of experimental ascites and solid tumor, DiPaolo's method gave nearly satisfactory results, but in the tests with human cancer cells the method was proved to be available only in 40 per cent of the cases. The uric acid level in the serum of rats bearing AH 130 tumor rose after the administration of anticancer drugs. However, the level did not rise in patients with stomach cancer given with 0.2mg Mitomycin per kg; even in the cases where cancer cells had been proved to be sensitive to the agents by DiPaolo's method, an elevation of the level did not take place after cancer chemotherapy, except in one case treated with Ititromin.

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