Improvement in Reliability of Probabilistic Test of Significant Differences in GeneChip Experiments

DOI PDF Web Site Web Site Web Site View 1 Remaining Hide 20 References

Search this article

Abstract

A probabilistic test (FUMI theory) for GeneChip experiments has been proposed for selecting the genes which show significant differences in the gene expression levels between a single pair of treatment and control. This paper describes that the reliability of the judgment by the FUMI theory can be enhanced, when the selected genes are referred to biomolecular-functional networks of a commercial database. The genes judged as being differently expressed are grouped into a cluster in the biomolecular networks. It is also demonstrated that false positive genes have a trend in the networks to be isolated from each other, and also away from the clustered genes, since the false positive genes are randomly selected.

Journal

  • Analytical Sciences

    Analytical Sciences 20 (4), 731-733, 2004

    The Japan Society for Analytical Chemistry

References(20)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top