Polytetrafluorethylene Film-Based Liquid-Three Phase Micro Extraction Coupled with Differential Pulse Voltammetry for The Determination of Atorvastatin Calcium
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- ENSAFI Ali A.
- Department of Chemistry, Isfahan University of Technology
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- KHODDAMI Elaheh
- Department of Chemistry, Isfahan University of Technology
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- REZAEI Behzad
- Department of Chemistry, Isfahan University of Technology
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In this paper, we describe a new combination method based on polytetrafluorethylene (PTFE) film-based liquid three-phase micro extraction coupled with differential pulse voltammetry (DPV) for the micro extraction and quantification of atorvastatin calcium (ATC) at the ultra-trace level. Different factors affecting the liquid-three phases micro extraction of atorvastatin calcium, including organic solvent, pH of the donor and acceptor phases, concentration of salt, extraction time, stirring rate and electrochemical factors, were investigated, and the optimal extraction conditions were established. The final stable signal was achieved after a 50 min extraction time, which was used for analytical applications. An enrichment factor of 21 was achieved, and the relative standard deviation (RSD) of the method was 4.5% (n = 4). Differential pulse voltammetry exhibited two wide linear dynamic ranges of 20.0 – 1000.0 pmol L−1 and 0.001 – 11.0 μmol L−1 of ATC. The detection limit was found to be 8.1 pmol L−1 ATC. Finally, the proposed method was used as a new combination method for the determination of atorvastatin calcium in real samples, such as human urine and plasma.
収録刊行物
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- Analytical Sciences
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Analytical Sciences 29 (3), 303-309, 2013
社団法人 日本分析化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204259575168
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- NII論文ID
- 10031165315
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- NII書誌ID
- AA10500785
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- COI
- 1:STN:280:DC%2BC3svkvVWhtA%3D%3D
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- ISSN
- 13482246
- 09106340
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- NDL書誌ID
- 024316102
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- PubMed
- 23474719
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- Web Site
- http://id.ndl.go.jp/bib/024316102
- https://ndlsearch.ndl.go.jp/books/R000000004-I024316102
- https://link.springer.com/content/pdf/10.2116/analsci.29.303.pdf
- https://link.springer.com/article/10.2116/analsci.29.303/fulltext.html
- https://www.jstage.jst.go.jp/article/analsci/29/3/29_303/_pdf
- https://search.jamas.or.jp/link/ui/2013250124
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- 本文言語コード
- en
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- JaLC
- NDL
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- PubMed
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