マグネシウム欠乏ラットひ臓のヒスタミン含有細胞

  • 石黒 茂
    鹿児島大学農学部家畜薬理学教室
  • 西尾 晃
    鹿児島大学農学部家畜薬理学教室
  • 宮尾 陟
    鹿児島大学農学部家畜薬理学教室
  • 森川 嘉夫
    大阪府立大学農学部家畜解剖学教室
  • 竹野 一
    大阪府立大学農学部家畜薬理学教室 鳥取大学農学部
  • 柳谷 岩雄
    大阪府立大学農学部家畜薬理学教室 科研製薬株式会社

書誌事項

タイトル別名
  • Studies on histamine containing cells in the spleen of the magnesium-deficient rats.
  • マグネシウム ケツボウ ラット ヒゾウ ノ ヒスタミン ガンユウ サイボウ

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抄録

When young Wistar rats (body wt. 50 g) were maintained on a magnesium-deficient diet (0.001% Mg) for eight days, the splenic weight and histamine content increased about 2-fold and 30-fold, respectively, compared with those of the control rats. There was no significant difference in the number of splenic mast cells between the magnesium-deficient and control rats. More neutrophilic, eosinophilic and basophilic granular cells were found in the spleen cells isolated from the magnesium-deficient rats than in those from the control rats. Of the isolated cells from magnesium-deficient rats, 7.6% were basophilic granular cells; however, no basophilic granular cells were observed in the spleen cells isolated from the control rats. In the cytochemical study, the yellowish fluorochrome formed by the interaction of o-phthalaldehyde and histamine was found in basophilic granular cells. These results suggest that the increase in the histamine content of the spleen of magnesium-deficient rats is related to the increased number of basophilic granular cells.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 90 (3), 141-146, 1987

    公益社団法人 日本薬理学会

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