書誌事項
- タイトル別名
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- Simultaneous measurements of anti-exudation and anti-granulation activities of antiinflammatory steroids
- コウエンショウ ステロイド ノ コウシンシュツサヨウ オヨビ コウニクガ サヨウ ノ ドウジ ソクテイ ニ ツイテ
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説明
The Selye's granuloma pouch method of anti-inflammatory assay was improved by injecting nitrogen gas instead of air for making a subcutaneous pouch in the back of the rat. Croton oil inflamed exdation in the nitrogen-pouch was much greater in the exudate volume and apparently smaller in the variance of individual volume when compared with the croton oil exudation in the air-pouch. Accordingly, the precision of antiexudation assay was improved. It was further demonstrated that the previously reported formalin-filterpaper-pellet method could be additionally applied in the rats bearing the nitrogen-pouch exudation, so that the simultaneous measurements of anti-granulation and anti-exudation activities of the test compound were available. Structure-activity relations of various pregn-4-ene derivatives were reinvestigated by the above method, and it was concluded that anti-exudation activities of steroidal compounds did not necessarily corelate with their anti-granulation activities: antiexudation activity of progesterone was increased by 17α-hydroxylation but decreased by 21-hydroxylation, and the coexistence of 11β-OH and 21-OH was needed for the manifestation of granuloma inhibition and of adrenal and thymus involution.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 66 (3), 316-325, 1970
公益社団法人 日本薬理学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390001204271060992
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- NII論文ID
- 130000757418
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- NII書誌ID
- AN00198335
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- COI
- 1:CAS:528:DyaE3MXltlOiu7g%3D
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- ISSN
- 13478397
- 00155691
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- NDL書誌ID
- 8404059
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- PubMed
- 5465627
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可